Our Research Group aims to develop intelligent drug carriers, theranostic platforms and robotic nanodevices empowered by nanobiotechnology, capable of dealing with the complex and dynamic biological microenvironment and acting with high safety, reliability, and efficacy in vivo. By exploiting the immense design and multifunctional flexibility of nanomaterials, we aspire to precisely manipulate biological processes on molecular, cellular and whole-body levels, paving the way for new therapies against diseases ranging from cancer and cardiovascular problems to immune disorders. The ultimate goal of our research is to bridge the gap between cutting-edge nanotechnology and unmet clinical needs.

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A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

Nature Biotechnology, 2018
Combination of tumour-infarction therapy and chemotherapy via the co-delivery of doxorubicin and thrombin encapsulated in tumour-targeted nanoparticles

Nature Biomedical Engineering, 2020
Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines

Science Translational Medicine, 2021
Bacteria-derived nanovesicles enhance tumour vaccination by trained immunity

Nature Nanotechnology, 2023

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Research Highlights

Selected Recent Publications

The dynamic role of platelets in cancer progression and their therapeutic implications

Suping Li, Zefang Lu, Suying Wu, Tianjiao Chu, Bozhao Li, Feilong Qi, Yuliang Zhao, Guangjun Nie*

Nature Reviews Cancer, 2023

Platelet-Mimicking Nanosponges for Functional Reversal of Antiplatelet Agents

Junchao Xu, Na Yan, Chunling Wang, Chao Gao, Xuexiang Han, Chengzhi Yang, Jiaqi Xu, Kun Wang, Michael J. Mitchell, Yinlong Zhang and Guangjun Nie*

Circulation Research, 2023

Biosynthesized gold nanoparticles that activate Toll-like receptors and elicit localized light-converting hyperthermia for pleiotropic tumor immunoregulation

Hao Qin, Yang Chen, Zeming Wang, Nan Li, Qing Sun, Yixuan Lin, Wenyi Qiu, Yuting Qin, Long Chen, Hanqing Chen, Yiye Li, Jian Shi, Guangjun Nie*, Ruifang Zhao*

Nature Communications, 2023